CD38 is a signaling molecule in B-chronic lymphocytic leukemia cells
نویسندگان
چکیده
From the 1 Laboratory of Immunogenetics, Department of Genetics, Biology and Biochemistry, the 2 Research Center on Experimental Medicine (CeRMS) and the 3 Department of Medicine and Experimental Oncology, all at the University of Torino Medical School, Torino, Italy; 4 Department of Hematology, University Hospital, Essen, Germany, and 5 Bone Marrow Transplant Center, “Bianchi Melacrino Morelli” Hospital, Reggio Calabria, Italy.
منابع مشابه
Immunophenotypic Characterization of the Leukemic B-cells from Iranian Patients with Chronic Lymphocytic Leukemia: Association between CD38 Expression and Disease Progression
Background: Patients with B-cell chronic lymphocytic leukemia (B-CLL) have hetero-geneous clinical courses, thus several biological parameters need to be added to the cur-rent clinical staging systems to predict disease outcome. Recent immunophenotypic stud-ies performed mainly in Western populations have demonstrated the prognostic value of CD38 and ZAP-70 expression in B-CLL. Objectives: To i...
متن کاملAnalysis of HLA-G Gene Expression in B-Lymphocytes from Chronic Lymphocytic Leukemia Patients
The human leukocyte antigen G (HLA-G) molecule exhibits limited tissue distribution, low polymorphism and alternative splicings that generate seven HLA-G isoforms. HLA-G exerts multiple immunoregulatory functions. Recent studies indicate an ectopic up-regulation in tumor cells that may favor their escape from anti-tumor immune responses. This study it is an effort to clarify the presence of HLA...
متن کاملAssociation between rs 1800561 CD38 Gene Polymorphism and Chronic Lymphocytic Leukemia Risk
Background and purpose: Chronic lymphocytic leukemia (CLL) is the most common form of adult leukemia characterized by the accumulation of seemingly mature type B lymphocytes in peripheral blood and lymphatic organs. One of the main markers used in the diagnosis and prognosis of CLL is the CD38 gene. Polymorphism is considered to be a major genetic source of phenotypic change within a species an...
متن کاملCD38 gene polymorphisms and genetic susceptibility to chronic lymphocytic leukemia
Introduction: CLL is one of the most common leukemias, which is categorized by the accumulation of mature CD5+ B-lymphocytes in the peripheral blood, bone marrow, and secondary lymphoid organs. In this study, the status of rs6449182 polymorphism of the CD38 gene and its association with clinical and laboratory parameters of CLL patients was evaluated. Methods: Genomic DNA extraction was perfor...
متن کاملCD38 is a signaling molecule in B-cell chronic lymphocytic leukemia cells.
The prognosis for patients with B-cell chronic lymphocytic leukemia (B-CLL) is generally less favorable for those expressing CD38. Our working hypothesis is that CD38 is not merely a marker in B-CLL, but that it plays a receptor role with pathogenetic potential ruling the proliferation of the malignant clone. CD38 levels were generally low in the patients examined and monoclonal antibody (mAb) ...
متن کاملCD38 expression labels an activated subset within chronic lymphocytic leukemia clones enriched in proliferating B cells.
Chronic lymphocytic leukemia (CLL) cells are thought to have diminished cell-cycling capacity, a view challenged by their phenotypic resemblance to activated human B lymphocytes. The present study addresses the cell-cycling status of CLL cells, focusing on those leukemic cells expressing CD38, a molecule involved in signaling and activation that also serves as a prognostic marker in this diseas...
متن کامل